| Schneyer Mark C. | EVP, CHIEF FINANCIAL OFFICER | 14,292Common Stock | $369.7K | Sell | |
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| Schneyer Mark C. | EVP, CHIEF FINANCIAL OFFICER | 14,292Common Stock | $369.7K | Option exercise | |
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| Schneyer Mark C. | EVP, CHIEF FINANCIAL OFFICER | 5,849Common Stock | $151.3K | Sell | |
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| Schneyer Mark C. | EVP, CHIEF FINANCIAL OFFICER | 5,849Common Stock | $151.3K | Option exercise | |
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| Thompson Elizabeth H.Z. | EVP, Head of Research & Dev | 16,558Common Stock | $411.3K | Sell | |
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| Thompson Elizabeth H.Z. | EVP, Head of Research & Dev | 32,272Common Stock | $801.6K | Exercise / conversion | |
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| Kihara James | PRINCIPAL ACCOUNTING OFFICER | 11,421Common Stock | $289.2K | Sell | |
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| BAKER BROS. ADVISORS LP | Director, 10% Owner | 32,008Non- Qualified Stock Option (right to buy) | $693.3K | Grant / award | |
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| BAKER BROS. ADVISORS LP | Director, 10% Owner | 18,622Common Stock | $403.4K | Grant / award | |
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| HARRIGAN EDMUND | Director | 9,311Restricted Stock Units | $201.7K | Grant / award | |
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