| RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | 70,000Common Stock | $816.2K | Option exercise | |
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| Thomas Stephen Basil | Director | 100,000Common Stock | $1.4M | Sell | |
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| Celebi Breanna Maurine | Director | 70,284Stock Option (Right to Buy) | $919.3K | Grant / award | |
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| RA CAPITAL MANAGEMENT, L.P. | Director, 10% Owner | 70,284Stock Option (Right to Buy) | $919.3K | Grant / award | |
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| Brennan Aoife | President and CEO | 30,902Common Stock | $404.2K | Sell | |
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| Brennan Aoife | President and CEO | 68,750Common Stock | $899.3K | Exercise / conversion | |
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| Dunn Judith | Director | 40,000Stock Option (Right to Buy) | $422K | Grant / award | |
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| Thomas Stephen Basil | Director | 40,000Stock Option (Right to Buy) | $422K | Grant / award | |
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| Cumbo Alexander | Director | 40,000Stock Option (Right to Buy) | $422K | Grant / award | |
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| WILLIAMS DOUGLAS E | Director | 40,000Stock Option (Right to Buy) | $422K | Grant / award | |
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