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IIONIS PHARMACEUTICALS INC

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IONIS PHARMACEUTICALS INC

$45.75Close · Sep 22, 2026
  • Overview
  • Financial statements
  • Metrics
    • Revenue & profit
    • Revenue by segment
    • Launches
    • Revenue concentration
    • Margins
    • Contracted revenue
    • Off-balance-sheet commitments
    • Cash flow
    • Cash & debt
    • Earnings per share
    • P/E ratio
    • Share count & dilution
  • Quarterly earnings
  • Burn Rate
  • Similar companies
  • History
  • Insider Transactions
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Metrics

Revenue & profit
Revenue by segment
Margins
Contracted revenue
Cash flow
Cash & debt
Earnings per share
Share count & dilution

Metrics

Compare sales with the profit left after direct costs and the profit left after all expenses and taxes.Formula: Gross profit = revenue − cost of revenue Net income = total income − total expenses
Q2 ’26201720182019202020212022202320242025-200M0200M400MLatest period Q2 '26. Revenue 267.95M. Gross profit 265.21M. Net profit -114.65M.
RevenueGross profitNet profit
See which business lines, products, or regions generate the company’s sales.Formula: Company revenue = Σ(segment revenues) + reconciliation adjustments
Q2 ’262017201820192020202120222023202420250100M200M300M400M500MLatest period Q2 '26. Spinraza Royalties 53.49M. Collaborative Agreement Revenue 133.14M. Wainua Joint Development Revenue 16.19M. Wainus Royalties 16.44M. Other Commercial 11.53M. Other Royalties 6.04M. Tryngolza 4.57M. DAWNZERA Sales 26.57M.
Licensing And Other RoyaltiesResearch And Development Under Collaborative AgreementsSpinraza RoyaltiesResearch And Development Revenue Under Collaborative AgreementsProductTEGSEDI Product SalesEplontersen Joint Development RevenueResearch And Development RevenueCollaborative Agreement RevenueWainua Joint Development RevenueWainus RoyaltiesOther CommercialOther RoyaltiesTryngolzaDAWNZERA Sales
See how much of each dollar of sales remains after direct costs, after running the business, and after all expenses and taxes.Formula: Gross margin = gross profit ÷ revenue × 100% Operating margin = operating income ÷ revenue × 100% Net margin = net income ÷ revenue × 100%
Q2 ’26201720182019202020212022202320242025-100%0%100%Latest period Q2 '26. Gross margin 99%. Operating margin -38.2%. Net profit margin -42.8%.
Gross marginOperating marginNet profit margin
See the amounts the company has committed to pay that its balance sheet does not record yet: leases it has signed that have not started, unconditional purchase and other contractual commitments, and the most it could have to pay under guarantees and credit backstops. Amounts are as the filing reports them at each balance-sheet date.Formula: Commitments = leases not yet commenced + purchase & other commitments + maximum guarantee exposure
Q4 ’212017201820192020202120232024202520260200M400M600M800M1B1.2B
      Latest period Q4 '21. Purchase & other commitments 1.3B.
      Leases not yet commencedPurchase & other commitmentsGuarantees & contingent commitments
      Compare cash generated by the business, spending on long-lived assets, and what remains afterward.Formula: Free cash flow = operating cash flow − capital expenditures
      $
      Q2 ’26201720182019202020212022202320242025-500M0500M
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        • Capex: purchases of property, plant and equipment
        Latest period Q2 '26. Operating cash flow 565.5M. Capex -16.1M. Free cash flow 549.5M.
        Operating cash flowCapexFree cash flow
        Compare the company’s cash cushion with its borrowings. Negative net cash means debt is greater than cash.Formula: Net cash = cash − debt
        20262017201820192020202120222023202420250500M1B1.5B
            Latest period 2026. Cash 350.1M.
            CashDebtNet cash
            Profit for each share over the trailing 12 months, adjusted for stock splits.Formula: Earnings available to common shareholders ÷ weighted-average shares
            $/shareUsing split history cached 2026-09-23; assuming no new splits
            Q2 ’26201720182019202020212022202320242025-4.00-2.000.002.004.00
              • Earnings period 2017-01-01 to 2017-03-31. Shares as of 2017-03-31: 123,880,559 source shares.
              • Earnings period 2017-04-01 to 2017-06-30. Shares as of 2017-06-30: 124,146,356 source shares.
              • Earnings period 2017-07-01 to 2017-09-30. Shares as of 2017-09-30: 124,619,363 source shares.
              • Earnings period 2017-01-01 to 2017-12-31. Shares as of 2017-12-31: 124,976,373 source shares.
              • Earnings period 2018-01-01 to 2018-03-31. Shares as of 2018-03-31: 125,448,746 source shares.
              • Earnings period 2018-04-01 to 2018-06-30. Shares as of 2018-06-30: 137,156,361 source shares.
              • Earnings period 2018-07-01 to 2018-09-30. Shares as of 2018-09-30: 137,506,203 source shares.
              • Earnings period 2018-01-01 to 2018-12-31. Shares as of 2018-12-31: 137,928,828 source shares.
              • Earnings period 2019-01-01 to 2019-03-31. Shares as of 2019-03-31: 139,623,937 source shares.
              • Earnings period 2019-04-01 to 2019-06-30. Shares as of 2019-06-30: 140,393,074 source shares.
              • Earnings period 2019-07-01 to 2019-09-30. Shares as of 2019-09-30: 140,636,397 source shares.
              • Earnings period 2019-01-01 to 2019-12-31. Shares as of 2019-12-31: 140,339,615 source shares.
              • Earnings period 2020-01-01 to 2020-03-31. Shares as of 2020-03-31: 139,282,168 source shares.
              • Earnings period 2020-04-01 to 2020-06-30. Shares as of 2020-06-30: 139,489,405 source shares.
              • Earnings period 2020-07-01 to 2020-09-30. Shares as of 2020-09-30: 139,793,901 source shares.
              • Earnings period 2020-01-01 to 2020-12-31. Shares as of 2020-12-31: 140,365,594 source shares.
              • Earnings period 2021-01-01 to 2021-03-31. Shares as of 2021-03-31: 140,924,356 source shares.
              • Earnings period 2021-04-01 to 2021-06-30. Shares as of 2021-06-30: 141,021,583 source shares.
              • Earnings period 2021-07-01 to 2021-09-30. Shares as of 2021-09-30: 141,184,026 source shares.
              • Earnings period 2021-01-01 to 2021-12-31. Shares as of 2021-12-31: 141,210,015 source shares.
              • Earnings period 2022-01-01 to 2022-03-31. Shares as of 2022-03-31: 141,753,122 source shares.
              • Earnings period 2022-04-01 to 2022-06-30. Shares as of 2022-06-30: 141,830,659 source shares.
              • Earnings period 2022-07-01 to 2022-09-30. Shares as of 2022-09-30: 142,017,411 source shares.
              • Earnings period 2022-01-01 to 2022-12-31. Shares as of 2022-12-31: 142,057,736 source shares.
              • Earnings period 2023-01-01 to 2023-03-31. Shares as of 2023-03-31: 143,022,539 source shares.
              • Earnings period 2023-04-01 to 2023-06-30. Shares as of 2023-06-30: 143,167,414 source shares.
              • Earnings period 2023-07-01 to 2023-09-30. Shares as of 2023-09-30: 143,393,493 source shares.
              • Earnings period 2023-01-01 to 2023-12-31. Shares as of 2023-12-31: 144,340,526 source shares.
              • Earnings period 2024-01-01 to 2024-03-31. Shares as of 2024-03-31: 145,844,719 source shares.
              • Earnings period 2024-04-01 to 2024-06-30. Shares as of 2024-06-30: 146,025,246 source shares.
              • Earnings period 2024-07-01 to 2024-09-30. Shares as of 2024-09-30: 157,813,136 source shares.
              • Earnings period 2024-01-01 to 2024-12-31. Shares as of 2024-12-31: 157,908,815 source shares.
              • Earnings period 2025-01-01 to 2025-03-31. Shares as of 2025-03-31: 159,041,259 source shares.
              • Earnings period 2025-04-01 to 2025-06-30. Shares as of 2025-06-30: 159,196,782 source shares.
              • Earnings period 2025-07-01 to 2025-09-30. Shares as of 2025-09-30: 161,137,930 source shares.
              • Earnings period 2025-01-01 to 2025-12-31. Shares as of 2025-12-31: 163,304,875 source shares.
              • Earnings period 2026-01-01 to 2026-03-31. Shares as of 2026-03-31: 165,902,064 source shares.
              • Earnings period 2026-04-01 to 2026-06-30. Shares as of 2026-06-30: 165,636,792 source shares.
              Latest period Q2 2026. EPS (TTM) -3.41.
              EPS (TTM)
              How much investors pay for each dollar of the company’s yearly earnings. It is not useful when the company has no profit.Formula: Share price ÷ trailing 12-month EPS
              Using split history cached 2026-09-23; assuming no new splits
              Q2 ’26201720182019202020212022202320242025-1,500x-1,000x-500x0x500x
                • Earnings period 2017-01-01 to 2017-03-31. Shares as of 2017-03-31: 123,880,559 source shares. Weekly price on 2017-03-31.
                • Earnings period 2017-04-01 to 2017-06-30. Shares as of 2017-06-30: 124,146,356 source shares. Weekly price on 2017-06-30.
                • Earnings period 2017-07-01 to 2017-09-30. Shares as of 2017-09-30: 124,619,363 source shares. Nearby weekly price on 2017-09-29.
                • Earnings period 2017-01-01 to 2017-12-31. Shares as of 2017-12-31: 124,976,373 source shares. Nearby weekly price on 2017-12-29.
                • Earnings period 2018-01-01 to 2018-03-31. Shares as of 2018-03-31: 125,448,746 source shares. Nearby weekly price on 2018-03-29.
                • Earnings period 2018-04-01 to 2018-06-30. Shares as of 2018-06-30: 137,156,361 source shares. Nearby weekly price on 2018-06-29.
                • Earnings period 2018-07-01 to 2018-09-30. Shares as of 2018-09-30: 137,506,203 source shares. Nearby weekly price on 2018-09-28.
                • Earnings period 2018-01-01 to 2018-12-31. Shares as of 2018-12-31: 137,928,828 source shares. Nearby weekly price on 2018-12-28.
                • Earnings period 2019-01-01 to 2019-03-31. Shares as of 2019-03-31: 139,623,937 source shares. Nearby weekly price on 2019-03-29.
                • Earnings period 2019-04-01 to 2019-06-30. Shares as of 2019-06-30: 140,393,074 source shares. Nearby weekly price on 2019-06-28.
                • Earnings period 2019-07-01 to 2019-09-30. Shares as of 2019-09-30: 140,636,397 source shares. Nearby weekly price on 2019-09-27.
                • Earnings period 2019-01-01 to 2019-12-31. Shares as of 2019-12-31: 140,339,615 source shares. Nearby weekly price on 2020-01-03.
                • Earnings period 2020-01-01 to 2020-03-31. Shares as of 2020-03-31: 139,282,168 source shares. Nearby weekly price on 2020-04-03.
                • Earnings period 2020-04-01 to 2020-06-30. Shares as of 2020-06-30: 139,489,405 source shares. Nearby weekly price on 2020-07-02.
                • Earnings period 2020-07-01 to 2020-09-30. Shares as of 2020-09-30: 139,793,901 source shares. Nearby weekly price on 2020-10-02.
                • Earnings period 2020-01-01 to 2020-12-31. Shares as of 2020-12-31: 140,365,594 source shares. Weekly price on 2020-12-31.
                • Earnings period 2021-01-01 to 2021-03-31. Shares as of 2021-03-31: 140,924,356 source shares. Nearby weekly price on 2021-04-01.
                • Earnings period 2021-04-01 to 2021-06-30. Shares as of 2021-06-30: 141,021,583 source shares. Nearby weekly price on 2021-07-02.
                • Earnings period 2021-07-01 to 2021-09-30. Shares as of 2021-09-30: 141,184,026 source shares. Nearby weekly price on 2021-10-01.
                • Earnings period 2021-01-01 to 2021-12-31. Shares as of 2021-12-31: 141,210,015 source shares. Weekly price on 2021-12-31.
                • Earnings period 2022-01-01 to 2022-03-31. Shares as of 2022-03-31: 141,753,122 source shares. Nearby weekly price on 2022-04-01.
                • Earnings period 2022-04-01 to 2022-06-30. Shares as of 2022-06-30: 141,830,659 source shares. Nearby weekly price on 2022-07-01.
                • Earnings period 2022-07-01 to 2022-09-30. Shares as of 2022-09-30: 142,017,411 source shares. Weekly price on 2022-09-30.
                • Earnings period 2022-01-01 to 2022-12-31. Shares as of 2022-12-31: 142,057,736 source shares. Nearby weekly price on 2022-12-30.
                • Earnings period 2023-01-01 to 2023-03-31. Shares as of 2023-03-31: 143,022,539 source shares. Weekly price on 2023-03-31.
                • Earnings period 2023-04-01 to 2023-06-30. Shares as of 2023-06-30: 143,167,414 source shares. Weekly price on 2023-06-30.
                • Earnings period 2023-07-01 to 2023-09-30. Shares as of 2023-09-30: 143,393,493 source shares. Nearby weekly price on 2023-09-29.
                • Earnings period 2023-01-01 to 2023-12-31. Shares as of 2023-12-31: 144,340,526 source shares. Nearby weekly price on 2023-12-29.
                • Earnings period 2024-01-01 to 2024-03-31. Shares as of 2024-03-31: 145,844,719 source shares. Nearby weekly price on 2024-03-28.
                • Earnings period 2024-04-01 to 2024-06-30. Shares as of 2024-06-30: 146,025,246 source shares. Nearby weekly price on 2024-06-28.
                • Earnings period 2024-07-01 to 2024-09-30. Shares as of 2024-09-30: 157,813,136 source shares. Nearby weekly price on 2024-09-27.
                • Earnings period 2024-01-01 to 2024-12-31. Shares as of 2024-12-31: 157,908,815 source shares. Nearby weekly price on 2025-01-03.
                • Earnings period 2025-01-01 to 2025-03-31. Shares as of 2025-03-31: 159,041,259 source shares. Nearby weekly price on 2025-03-28.
                • Earnings period 2025-04-01 to 2025-06-30. Shares as of 2025-06-30: 159,196,782 source shares. Nearby weekly price on 2025-06-27.
                • Earnings period 2025-07-01 to 2025-09-30. Shares as of 2025-09-30: 161,137,930 source shares. Nearby weekly price on 2025-10-03.
                • Earnings period 2025-01-01 to 2025-12-31. Shares as of 2025-12-31: 163,304,875 source shares. Nearby weekly price on 2026-01-02.
                • Earnings period 2026-01-01 to 2026-03-31. Shares as of 2026-03-31: 165,902,064 source shares. Nearby weekly price on 2026-04-02.
                • Earnings period 2026-04-01 to 2026-06-30. Shares as of 2026-06-30: 165,636,792 source shares. Nearby weekly price on 2026-07-02.
                Latest period Q2 2026. P/E ratio -24x.
                P/E ratio
                See how the number of shares changes over time. More shares can mean each existing share owns a smaller slice of the company.Formula: Outstanding shares = issued shares − treasury shares Share-count growth = (current shares ÷ previous shares − 1) × 100%
                Stock split history may be out of date.
                2026201720182019202020212022202320242025050M100M150M
                    Latest period 2026. Shares outstanding 165.6M. Class detail unavailable 165.6M.
                    Class detail unavailable