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Kim Kraig Thompson, a retired lawyer, invented the protein expression platform in 2002, which would become the basis for Kraig Lab's work with spider silk. He founded Kraig Biocraft Laboratories in April 2006 to develop and commercialize spider silks and other high-performance polymers gene and sequences using platform technology in combination with genetic engineering concepts.
The original scientific work to reduce Thompson's invention to practice was performed in the biological laboratories of the University of Notre Dame. The University of Notre Dame was chosen in large part because the co-inventor of the PiggyBac transposon system, Malcom Fraser, was in residence there. This transposon was utilized by Kraig Labs and the University of Notre Dame to create the world's first transgenic silkworm producing recombinant spider silk. This work was subsequently the subject of a peer-reviewed article in the publication of the National Academy of Sciences (PNAS).
In 2011, Sigma-Aldrich started developing genetically modified silkworms in partnership with Kraig Biocraft Laboratories in order to produce spider silk.
In 2019, the company's wholly owned subsidiary, Prodigy Textiles LLC, established production facility in Vietnam for the production of spider silk.