| BAKER BROS. ADVISORS LP | Director, 10% Owner | 33,726Common Stock | $3M | Buy | |
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| BAKER BROS. ADVISORS LP | Director, 10% Owner | 1,908,029Common Stock | $171.6M | Buy | |
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| PERLROTH VICTOR | Chairman and CEO | 1,280,524Common Stock | $41.4M | Option exercise | |
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| BORGESON JOHN A. | Chief Financial Officer | 66,500Stock Option (Right to Buy) | $2.7M | Grant / award | |
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| PERLROTH VICTOR | Chairman and CEO | 100,000Stock Option (Right to Buy) | $4.1M | Grant / award | |
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| PROFUSEK ROBERT | Director | 17,731Stock Option (Right to Buy) | $637.3K | Grant / award | |
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| BAKER BROS. ADVISORS LP | Director, 10% Owner | 17,731Non-Qualified Stock Options (right to buy) | $637.3K | Grant / award | |
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| Yang Taiyin | Director | 17,731Stock Option (Right to Buy) | $637.3K | Grant / award | |
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| Levy Richard S | Director | 17,731Stock Option (Right to Buy) | $637.3K | Grant / award | |
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| Bancroft Charles A | Director | 17,731Stock Option (Right to Buy) | $637.3K | Grant / award | |
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