| Sibold William John | President and CEO | 5,221Common Stock | — | Sell | |
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| Sibold William John | President and CEO | 6,362Common Stock | — | Sell | |
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| Kelley Shannon T | General Counsel | 664Common Stock | — | Sell | |
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| REED JOHN C | Director | 1,078Stock Option (Right to Buy) | — | Grant / award | |
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| REED JOHN C | Director | 647Common Stock | — | Grant / award | |
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| Sibold William John | President and CEO | 2,500Common Stock | — | Sell | |
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| Sibold William John | President and CEO | 50,000Common Stock | — | Exercise / conversion | |
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| BAKER BROS. ADVISORS LP | Director | 1,532Non-Qualified Stock Options (right to buy) | — | Grant / award | |
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| BAKER BROS. ADVISORS LP | Director | 908Common Stock | — | Grant / award | |
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| Brennan Daniel J. | Director | 681Stock Option (Right to Buy) | — | Grant / award | |
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