Nanobiotix S.A.

Nanobiotix is a spin-off of the State University of New York ( SUNY ) at Buffalo that was incorporated in 2003 and has been primarily funded by leading European venture capital firms (Matignon Technologies, OTC Asset Management, Cap Decisif, Amorcage Rhone-Alpes, CIC Vizille; Masseran Gestion-CGE).

Nanobiotix, founded in 2003 based on research by Laurent Levy at SUNY Buffalo. Between 2007 and 2010, the company focused on the development of the NanoXray research program. In 2011, Nanobiotix initiated its first Phase I/II clinical study on NBTXR3 in humans, marking the commencement of treatment for the first patient in the study.

The company went public in 2012, listing on the Euronext Paris market and establishing a partnership with PharmaEngine. By 2014, Nanobiotix expanded its presence to the United States with the creation of its first US subsidiary in Cambridge, Massachusetts. In 2015, the company started its first clinical trial in the United States, targeting prostate cancer with NBTXR3.

In 2017, Nanobiotix opened a new facility to expand its manufacturing capabilities, increase production capacity, and prepare for commercialization. The same year, the FDA approved Nanobiotix's first immuno-oncology trial in the US, and the company opened two new affiliates in Germany and Spain.

Positive Phase II/III results for NBTXR3 in soft tissue sarcoma were reported in 2018. In 2019, Nanobiotix launched nine new Phase I/II clinical trials treating six cancer indications and involving 340 patients at the University of Texas MD Anderson Cancer Center. The company also received European market approval (CE marking) for NBTXR3 (Hensify®) for the treatment of locally advanced soft tissue sarcoma. Additionally, Nanobiotix established a new subsidiary, Curadigm, aimed at optimizing therapeutic balance across the pharmaceutical industry, and was awarded the 2019 Prix Galien Award for NBTXR3.

In 2020, the U.S. FDA granted Fast Track designation for the investigation of NBTXR3 in head and neck cancer.