PALISADE BIO, INC.

Canadian clearance supports site activation and enrollment in the global study of once-daily oral PALI-2108 Primary efficacy results from approximately 204 patients with moderately to severely active ulcerative colitis expected in the second half of 2027 Denver, CO, Sept. 23, 2026 (GLOBE NEWSWIRE) — Palisade Bio, Inc. (Nasdaq: PALI) (“Palisade” or the “Company”), a clinical-stage biopharmaceutical company developing next-generation prodrugs for patients living with inflammatory and fibrotic diseases, today announced that Health Canada has cleared the Company’s Clinical Trial Application (CTA) for ASCENTRA-UC, its global Phase 2 study evaluating PALI-2108 in patients with moderately to severely active ulcerative colitis (UC). The clearance enables Palisade to advance clinical trial activities in Canada, expanding the study’s geographic reach and supporting planned enrollment. Together with prior regulatory clearance in the United States, this milestone advances the Company’s global site activation and enrollment strategy. Primary efficacy results from the study’s 12-week induction period are expected in the second half of 2027. “Health Canada clearance represents another important execution milestone as we advance ASCENTRA-UC globally,” said JD Finley, Chief Executive Officer of Palisade Bio. “Our focus is on efficiently activating sites, expanding patient access to the study and delivering the clinical data needed to define […]

ASCENTRA-CD expected to enroll approximately 60 patients with moderate to severe Crohn’s disease First patient dosing targeted for Q1 2027; primary efficacy readout (Week 12 endoscopic response) targeted for Q1 2028 Phase 2 program builds on clinical experience in fibrostenotic Crohn’s disease demonstrating targeted tissue exposure, PDE4 target engagement and encouraging endoscopic activity Denver, CO, Sept. 22, 2026 (GLOBE NEWSWIRE) — Palisade Bio, Inc. (Nasdaq: PALI) (“Palisade” or the “Company”), a clinical-stage biopharmaceutical company developing next-generation prodrugs for patients living with inflammatory and fibrotic diseases, today announced that the U.S. Food and Drug Administration (FDA) has cleared the Company’s Investigational New Drug (IND) application for PALI-2108, enabling initiation of the Phase 2 ASCENTRA-CD clinical trial in patients with moderate to severe Crohn’s disease (CD). “FDA clearance of the ASCENTRA-CD IND marks another significant milestone for PALI-2108 and meaningfully expands our Phase 2 development program across inflammatory bowel disease,” said Mitch Jones, M.D., Ph.D., President and Chief Medical Officer of Palisade Bio. “Crohn’s disease remains a progressive condition where many patients experience inadequate response or loss of response to existing therapies. We believe PALI-2108’s differentiated prodrug design, once-daily oral dosing and targeted activation within the ileum and colon provide a compelling […]

Presentation scheduled for September 23, 2026 at 1:00 PM ET Access the webcast here Denver, CO, Sept. 21, 2026 (GLOBE NEWSWIRE) — Palisade Bio, Inc. (Nasdaq: PALI) (“Palisade” or the “Company”), a clinical-stage biopharmaceutical company developing next-generation prodrugs for patients living with inflammatory and fibrotic diseases, today announced that JD Finley, Chief Executive Officer, and Mitchell Jones, M.D., Ph.D., President and Chief Medical Officer, will participate in the Stifel 2026 Virtual Immunology and Inflammation Forum. Date: September 23, 2026Time: 1:00 PM – 1:25 PM ETPresenters: JD Finley, Chief Executive Officer; Mitchell Jones, President & Chief Medical OfficerFormat: Virtual The presentation will provide an update on the Company’s PALI-2108 clinical development program, including recent progress across ulcerative colitis and Crohn’s disease, the expanding clinical and translational data supporting PALI-2108’s differentiated profile, and upcoming development milestones. A live webcast of the presentation will be accessible on the Events page in the Investors section of the Company’s website at palisadebio.com. A replay will be available following the live event and will be archived for a limited time. In addition to the presentation, management will be available to participate in one-on-one meetings with qualified members of the investor community who are registered for the […]

Denver, CO, Sept. 03, 2026 (GLOBE NEWSWIRE) — Palisade Bio, Inc. (Nasdaq: PALI) (“Palisade” or the “Company”), a clinical-stage biopharmaceutical company developing next-generation prodrugs for patients living with inflammatory and fibrotic diseases, today announced that members of management will participate in three healthcare investor conferences in September 2026. Wells Fargo 2026 Healthcare Conference Dates: September 8-10, 2026Location: Boston, MassachusettsFormat: Investor meetings Morgan Stanley 24th Annual Global Healthcare Conference Dates: September 14-16, 2026Location: New York, New YorkFireside Chat: Wednesday, September 16, 2026, from 10:00-10:35 AM ETFormat: In-person fireside chat and investor meetingsWebcast Registration H.C. Wainwright 28th Annual Global Investment Conference Dates: September 14-16, 2026Location: New York, NYPresentation: Wednesday, September 16, 2026, from 3:00-3:30 PM ETPresentation Location: Kennedy II, 4th FloorFormat: In-person fireside chat and investor meetingsWebcast Registration Investors interested in meeting with Palisade Bio management during the conferences should contact their respective conference representatives. Live webcasts of the fireside chats will be accessible on the Events page in the Investors section of the Company’s website at palisadebio.com. Replays will be available following the live events and will be archived for a limited time. About Palisade Bio Palisade Bio, Inc. (Nasdaq: PALI) is a clinical-stage biopharmaceutical company developing prodrugs for patients living […]

Advancing a potentially best-in-class once-daily oral, locally-activated PDE4 inhibitor prodrug specifically engineered for the treatment of inflammatory bowel disease (IBD) Enrollment of first patient for Phase 2 ASCENTRA-UC trial of PALI-2108 expected in the second half of 2026; primary efficacy results expected in the second half of 2027 IND for Phase 2 ASCENTRA-CD trial of PALI-2108 for the treatment of Crohn’s disease expected in the second half of 2026 Strong balance sheet expected to support execution through key Phase 2 clinical readouts Denver, CO, Aug. 10, 2026 (GLOBE NEWSWIRE) — Palisade Bio, Inc. (Nasdaq: PALI) (“Palisade Bio” or the “Company”), a clinical-stage biopharmaceutical company developing next-generation prodrugs for patients living with inflammatory and fibrotic diseases, today reported financial results for the second quarter ended June 30, 2026, and provided a business update. During the quarter, the Company completed key regulatory and operational activities supporting the planned commencement of the Phase 2 ASCENTRA-UC trial of PALI-2108 in the second half of 2026. Palisade Bio is advancing PALI-2108 into Phase 2 development for ulcerative colitis (UC) and Crohn’s disease (CD), supported by encouraging results from its completed Phase 1 clinical trial. Key Takeaways from the Phase 1 Clinical Trial Across the Phase […]

Management to participate in investor meetings on July 14-15 in Boston Denver, CO, July 10, 2026 (GLOBE NEWSWIRE) — Palisade Bio, Inc. (Nasdaq: PALI) (“Palisade” or the “Company”), a clinical-stage biopharmaceutical company developing next-generation oral PDE4 inhibitor prodrugs for inflammatory bowel disease, today announced that JD Finley, Chief Executive Officer, and Dr. Mitchell Jones, President & Chief Medical Officer, will participate in the Leerink Partners Therapeutics Forum, taking place July 14-15, 2026, in Boston, Massachusetts. Management will participate in one-on-one meetings with institutional investors throughout the conference to discuss the Company’s clinical development strategy, recent progress advancing PALI-2108 and upcoming milestones across its inflammatory bowel disease programs. About Palisade Bio Palisade Bio, Inc. (Nasdaq: PALI) is a clinical-stage biopharmaceutical company advancing a next-generation oral PDE4 inhibitor prodrug designed to improve pharmacology, tolerability and convenience for patients with inflammatory and fibrotic diseases. Through its prodrug platform and precision pharmacology strategy, Palisade Bio is committed to transforming proven PDE4 biology into improved oral therapies for patients living with chronic inflammatory and fibrotic diseases. The Company’s lead program, PALI-2108, is a once-daily oral PDE4 inhibitor prodrug designed to be selectively bioactivated in the ileum and colon, initiating targeted PDE4 inhibition at sites of […]

ASCENTRA-UC expected to enroll up to 204 patients with moderately to severely active ulcerative colitis across North America and Europe First patient enrollment anticipated in the second half of 2026; primary efficacy results expected in the second half of 2027 IND clearance marks a major development milestone for PALI-2108 and supports continued advancement of the Company’s inflammatory bowel disease portfolio Denver, CO, June 29, 2026 (GLOBE NEWSWIRE) — Palisade Bio, Inc. (Nasdaq: PALI) (“Palisade” or the “Company”), a clinical-stage biopharmaceutical company developing next-generation oral PDE4 inhibitor prodrugs for inflammatory bowel disease, today announced that the U.S. Food and Drug Administration (FDA) has cleared the Company’s Investigational New Drug (IND) application for PALI-2108, enabling initiation of the global Phase 2 ASCENTRA-UC clinical trial in patients with moderately to severely active ulcerative colitis (UC). The Company anticipates initiating patient enrollment in the second half of 2026, with primary efficacy results expected in the second half of 2027. “FDA clearance of our IND application is a significant milestone for Palisade Bio and an important validation of the extensive preclinical, manufacturing and clinical work completed to advance PALI-2108 into Phase 2 development,” said Mitch Jones, M.D., Ph.D., President and Chief Medical Officer of Palisade […]

Board strengthened with extensive biotechnology leadership, strategic transactions and capital markets expertise Company continues to build on PALI-2108 clinical progress as it advances toward Phase 2 development and additional key milestones Denver, CO, June 11, 2026 (GLOBE NEWSWIRE) — Palisade Bio, Inc. (Nasdaq: PALI) (“Palisade” or the “Company”), a clinical-stage biopharmaceutical company developing next-generation, once-daily, oral PDE4 inhibitor prodrugs designed for targeted delivery to the terminal ileum and colon, today announced the addition of Robert Baltera and Jordan Zwick to its Board of Directors. “We are pleased to welcome both Robert and Jordan to the Palisade Bio Board of Directors,” said JD Finley, Chief Executive Officer of Palisade Bio. “Their combined expertise across biotechnology company building, strategic transactions, capital markets, operational execution and corporate governance will provide meaningful value as we continue advancing PALI-2108 through clinical development and execute on our long-term growth strategy. Both executives have significant experience supporting innovative biotechnology companies through important stages of development, financing and value creation.” Mr. Baltera is a seasoned biopharmaceutical executive, board director and Senior Advisor at Frazier Life Sciences, with more than three decades of experience spanning company leadership, corporate strategy, product development, operations, manufacturing, commercial planning and strategic transactions. He […]

Presentation to highlight fibrostenotic Crohn’s disease biology and the potential of a locally bioactivated PDE4 inhibitor prodrug approach Denver, CO, June 09, 2026 (GLOBE NEWSWIRE) — Palisade Bio, Inc. (Nasdaq: PALI) (“Palisade” or the “Company”), a clinical-stage biopharmaceutical company developing next-generation, once-daily, oral PDE4 inhibitor prodrugs designed for targeted delivery to the terminal ileum and colon, today announced Mitchell Jones, MD, PhD, President and Chief Medical Officer, will present at the New York Academy of Sciences (“NYAS”) symposium, Molecular Pathways and Cellular Players in the Resolution of Organ Fibrosis, taking place on June 9, 2026, in New York, NY. The symposium brings together leading experts from academia, industry and clinical research to explore advances in fibrosis biology, emerging multiomic insights and the development of novel therapeutic approaches across a range of fibrotic diseases. Dr. Jones’ presentation, titled “Locally Bioactivated PDE4 Inhibitor Prodrug for the Treatment of Fibrostenotic Crohn’s Disease (FSCD),” will discuss the significant unmet need associated with FSCD, the biological mechanisms underlying intestinal fibrosis and the potential role of locally bioactivated PDE4 inhibition as a novel therapeutic approach. “Fibrosis remains one of the most significant challenges facing patients with Crohn’s disease, yet there are currently no approved therapies specifically […]