PRELUDE THERAPEUTICS INC

No buy/sell activity

Date	Name	Title	Shares	Value	Transaction
Jun 9, 2026	BAKER BROS. ADVISORS LP	Director, 10% Owner	38,000Non-Qualified Stock Option (right to buy)	—	Grant / award
Jun 9, 2026	FRIEDMAN PAUL A	Director	38,000Director Stock Option (Right to Buy)	—	Grant / award
Jun 9, 2026	Babler Martin	Director	38,000Director Stock Option (Right to Buy)	—	Grant / award
Jun 9, 2026	Bonita David P	Director, 10% Owner	38,000Director Stock Option (Right to Buy)	—	Grant / award
Jun 9, 2026	Dorton Katina	Director	38,000Director Stock Option (Right to Buy)	—	Grant / award
Jun 9, 2026	Sandor Victor	Director	38,000Director Stock Option (Right to Buy)	—	Grant / award
May 1, 2026	Morris Charles Q	Chief Medical Officer	450,000Employee Stock Option (right to buy)	—	Grant / award
Apr 27, 2026	RA CAPITAL MANAGEMENT, L.P.	10% Owner	1,407,000Pre-Funded Warrants (Right to Buy)	—	Other
Apr 27, 2026	RA CAPITAL MANAGEMENT, L.P.	10% Owner	1,407,000Common Stock	—	Other
Apr 21, 2026	ORBIMED ADVISORS LLC	Director, 10% Owner	2,815,315Common Stock	—	Buy