| Metzger Michael A | Chief Executive Officer | 32,375Stock Option (Right to buy) | — | Option exercise | |
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| Metzger Michael A | Chief Executive Officer | 32,375Common Stock | — | Sell | |
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| Metzger Michael A | Chief Executive Officer | 32,375Common Stock | — | Exercise / conversion | |
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| Botwood Nicholas A.J. | Head of R&D, CMO | 31,235Stock options (Right to buy) | — | Option exercise | |
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| Botwood Nicholas A.J. | Head of R&D, CMO | 31,235Common Stock | — | Sell | |
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| Botwood Nicholas A.J. | Head of R&D, CMO | 31,235Common Stock | — | Exercise / conversion | |
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| Botwood Nicholas A.J. | Head of R&D, CMO | 22,515Stock options (Right to buy) | — | Option exercise | |
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| Botwood Nicholas A.J. | Head of R&D, CMO | 34,280Common Stock | — | Sell | |
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| Botwood Nicholas A.J. | Head of R&D, CMO | 22,515Common Stock | — | Exercise / conversion | |
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| Metzger Michael A | Chief Executive Officer | 6,847Common Stock | — | Sell | |
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