| Smith Jason Drew | General Counsel | 1,519Ordinary Shares | — | Sell | |
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| Schoenberg Mark | Chief Medical Officer | 871Ordinary Shares | — | Sell | |
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| Smith Jason Drew | General Counsel | 3,334Ordinary Shares | — | Exercise / conversion | |
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| Schoenberg Mark | Chief Medical Officer | 1,667Ordinary Shares | — | Exercise / conversion | |
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| Robinson James A. Jr. | Director | 2,000ordinary shares | — | Exercise / conversion | |
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| Schoenberg Mark | Chief Medical Officer | 60,677ordinary shares | — | Sell | |
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| Schoenberg Mark | Chief Medical Officer | 10,000Ordinary Shares | — | Sell | |
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| Belldegrun Arie | Director | 20,000Stock Option (right ot buy) | — | Grant / award | |
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| WEN LEANA | Director | 8,000Restricted Stock Unit | — | Grant / award | |
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| WEN LEANA | Director | 10,000Stock Option (right ot buy) | — | Grant / award | |
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